Panic Room
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The 2002 David Fincher thriller starring Jodie Foster about a mother and daughter who barricade themselves in a fortified safe room during a home invasion. Niles mentions retreating to his panic room during Daphne's argument with Gertrude.
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Mentioned once in Some Assembly Required.
Some Assembly Required
Season 10 · Episode 19 · S10E19
“I couldn't hear you. I was in the panic room. But you looked very forceful on the monitor.”