Great Chicago Fire
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A conflagration that burned from October 8-10, 1871, destroying much of Chicago; popularly blamed on Mrs. O'Leary's cow.
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Mentioned once in Voyage Of The Damned.
Voyage Of The Damned
Season 5 · Episode 6 · S05E06
“A horny society boozer, and the Mrs. O'Leary's Cow of our current predicament! ... A woman in Chicago who — oh, I don't have the time!”