Black Death
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The Black Death (1347-1351) was a devastating pandemic that killed an estimated 30-60% of Europe's population. It has traditionally been attributed to bubonic plague spread by fleas on rats, though recent research has suggested it may have been anthrax.
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Mentioned once in The Apparent Trap.
The Apparent Trap
Season 7 · Episode 9 · S07E09
“Oh, now, nobody caught anything from a rat that wasn't resolved in a day or two, off you go.”