Little Orphan Annie
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A popular American comic strip character created by Harold Gray in 1924, known for her distinctive appearance with empty, pupil-less eyes.
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Mentioned once in The Three Faces Of Frasier.
The Three Faces Of Frasier
Season 7 · Episode 21 · S07E21
“Yes, well, neither did Little Orphan Annie, and she's got her own Broadway show, now go on, shoo!”